The Volume of Three-Dimensional Cultures of Cancer Cells In Vitro Influences Transcriptional Profile Differences and Similarities with Monolayer Cultures and Xenografted Tumors

Improving the congruity of preclinical models with cancer as it is manifested in humans is a potential way to mitigate the high attrition rate of new cancer therapies in the clinic.In this regard, three-dimensional (3D) tumor cultures in vitro have recently regained interest as they have been acclaimed to have higher similarity to tumors in vivo th

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Reconfigurable 3D CAD Feature Recognition Supporting Confluent n-Dimensional Topologies and Geometric Filters for Prismatic and Curved Models

Feature Recognition (FR) in Computer-aided Design (CAD) models is central for Design and Manufacturing.FR is a problem whose computational burden is intractable (NP-hard), given that its underlying task is the detection of graph isomorphism.Until now, compromises have been reached by only using FACE-based geometric information of prismatic CAD mode

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QTLs underlying the genetic interrelationship between efficient compatibility of Bradyrhizobium strains with soybean and genistein secretion by soybean roots.

Soybean plants establish symbiotic relationships with soil rhizobia which form nodules on the plant roots.Nodule formation starts when the plant roots exudate isoflavonoids that induce nod gene expression of a specific Bradyrhizobium.We examined the specific indigenous rhizobia that form nodules with the soybean cultivars Peking and Tamahomare in d

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